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Sulfamethoxazole

CAS Number
723-46-6
EC Number
211-963-3
Chemical Formula
C10H11N3O3S
Molecular Weight
253.28 g/mol

Description

Sulfamethoxazole (CAS 723-46-6 ), commonly abbreviated as SMX, is a sulfonamide antibacterial active pharmaceutical ingredient used in the manufacture of finished antimicrobial drug products. It is marketed under trade names including Urobak and Sinomin, and is most recognized globally as the fixed-dose combination partner with trimethoprim for various medical applications. SMX is the primary active ingredient in co-trimoxazole formulations, where it is combined with trimethoprim in a 5:1 ratio to produce tablets, suspensions, and injectable preparations. Pharmaceutical manufacturers source SMX as a bulk API for urinary tract infection treatments, which remains one of the highest-volume therapeutic categories globally for chemical suppliers. Generic drug producers rely on SMX to supply finished-dose forms across regulated and emerging markets. Contract formulators also use SMX in veterinary pharmaceutical preparations for livestock. Demand for sulfonamide-based antibacterials remains substantial in the global market. Sulfamethoxazole is supplied as a white crystalline powder in bulk quantities suited to commercial manufacturing. It is available to USP , BP , and Ph. Eur. pharmacopoeial specifications, supporting registration requirements across major regulated markets and international territories. Packaging is typically offered in fiber drums or double polyethylene-lined bags. Lot-specific CoA and full regulatory documentation are available upon request for all industrial orders. Contact us for supply of Sulfamethoxazole Request Quote

Other Names (Synonyms)

SMX | Urobak | Sinomin | Ro-42130 | Gantanol-Ds | Gantanol (tn) | Gantanol | 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point167 °C
Boiling Point482°C
Density1.08 g/cm³
Flash Point>110°(230°F)
Appearancesolid
ColorWhite to Pale Yellow
Formneat
Water SolubilitySoluble in ethanol or acetone. Very slightly soluble in water
Refractive Index1.6630 (estimate)

Safety & Handling

Warning
GHS07· IrritantGHS09· EnvironmentGHS08· Health Hazard

Hazard Statements

H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H350May cause cancer
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P391Collect spillage.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29350090
Storage Class11 - Combustible Solids
WGK (Germany)2