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S-adenosylmethionine

CAS Number
29908-03-0
EC Number
249-946-8
Chemical Formula
C15H22N6O5S
Molecular Weight
398.4 g/mol

Description

S-adenosylmethionine (CAS 29908-03-0 ), commonly known as SAMe or AdoMet, is a naturally occurring methyl donor central to enzymatic transmethylation reactions across pharmaceutical, nutraceutical, and biochemical research applications. It functions as a cosubstrate in over 100 enzymatic reactions, making it a high-value active ingredient in both finished dosage forms and research workflows. In pharmaceutical and nutraceutical manufacturing, SAMe is formulated into oral supplements. These prescription products target liver function support and mood-related indications. Biochemistry and drug discovery labs use AdoMet as a reference standard and reaction substrate in methyltransferase assays, epigenetics research, and enzyme kinetics studies. In cosmetic formulations, it is incorporated into anti-aging and skin-conditioning products where methyl donor activity supports cellular repair pathways relevant to formulators. Contract manufacturers producing enteric-coated tablets rely on stabilized SAMe salts. These salts protect the compound through processing and shelf life. S-adenosylmethionine is supplied primarily as a crystalline powder in stabilized salt forms, most commonly the tosylate disulfate and butanedisulfonate salts. Pharmaceutical-grade material is available to USP and BP specifications, while research-grade material is offered at defined purity levels for laboratory use. Packaging ranges from small quantities for R&D to bulk quantities for commercial manufacturing. Contact us for supply of S-adenosylmethionine Request Quote

Other Names (Synonyms)

AdoMet | SAM | SAMe | S-adenosyl-L-methionine | S-(5'-deoxyadenosin-5'-yl)-L-methionine | (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt | Active methionine | RefChem:53996

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

ColorWhite to Yellow
FormSolid

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H302Harmful if swallowed
H312Harmful in contact with skin
H319Causes serious eye irritation
H332Harmful if inhaled

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29349990