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Ethyl bromoacetate

CAS Number
105-36-2
EC Number
203-290-9
Chemical Formula
C4H7BrO2
Molecular Weight
167.00 g/mol

Description

Ethyl bromoacetate ( CAS 105-36-2 ), also known commercially as Antol, is a reactive alkylating ester used as a key building block in organic synthesis. It functions primarily as an intermediate in the manufacture of active pharmaceutical ingredients. The compound is essential for specialty chemicals, where its reactive bromomethyl group enables carbon-carbon and carbon-heteroatom bond formation. In pharmaceutical manufacturing, it serves as a precursor in the synthesis of amino acids and peptides. It is also used for a broad range of API scaffolds requiring acetic acid ester functionalization. Cosmetic and personal care formulators use it as a synthetic intermediate in fragrance molecule production for specific olfactory profiles. The chemical contributes to the construction of esters and lactones. It also has documented use as a biocidal and preservative agent in industrial applications, where its reactivity toward biological nucleophiles provides antimicrobial effect. In flavor and fragrance chemistry, Antol is referenced as a starting material for aroma compounds requiring bromoacetate chemistry. The product is supplied as a clear to pale yellow liquid for various industrial processes. It is available in technical and reagent grades, with purity specifications typically ranging from 97% to 99%+. Packaging options generally include drums and intermediate bulk containers suited to industrial procurement volumes. Contact us for supply of Ethyl bromoacetate Request Quote

Other Names (Synonyms)

ETHYL 2-BROMOACETATE | Antol | Bromoacetic acid ethyl ester | Ethyl bromacetate | Ethyl monobromoacetate | Acetic acid, bromo-, ethyl ester | Ethoxycarbonylmethyl bromide | Acetic acid, 2-bromo-, ethyl ester

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-38 °C
Boiling Point168.5 °C
Density1.5032 g/cm³ @ Temp: 20 °C
Flash Point118 °F
AppearanceEthyl bromoacetate is a clear, colorless to light-yellow liquid.
ColorClear
OdorPungent odour
FormLiquid
Water SolubilityMiscible with ethanol, acetone, benzene and ethyl ether. Immiscible with water.
Vapor Pressure2.6 mm Hg ( 25 °C)
Refractive Indexn 20/D 1.451(lit.)

Safety & Handling

Danger
GHS06· ToxicGHS02· FlammableGHS05· Corrosive

Hazard Statements

H226Flammable liquid and vapor
H300Fatal if swallowed
H310Fatal in contact with skin
H318Causes serious eye damage
H330Fatal if inhaled H300+H310+
H330Fatal if swallowed, in contact with skin or if inhaled

Precautionary Statements

P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284In case of inadequate ventilation wear respiratory protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P316Get emergency medical help immediately.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P364Take off immediately all contaminated clothing and wash it before reuse.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P235Store in a well-ventilated place. Keep cool.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29159080
UN Number1603
ADR Class6.1
Packing GroupII
Storage Class3 - Flammable liquids
WGK (Germany)1