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Solketal

CAS Number
100-79-8
EC Number
202-888-7
Chemical Formula
C6H12O3
Molecular Weight
132.16 g/mol

Description

Solketal (CAS 100-79-8 ), also known as Glycerol dimethylketal, is a cyclic acetal derived from glycerol used as a solvent, carrier, and chemical intermediate across pharmaceutical, cosmetic, and polymer applications. Its low toxicity profile and biodegradable character make it a preferred alternative to conventional solvents in formulations where regulatory compliance and sustainability drive sourcing decisions. In pharmaceutical manufacturing, this compound functions as a solvent and carrier for active ingredients, improving solubility and stability in oral and topical drug formulations. Cosmetic formulators incorporate it as a skin-conditioning carrier and co-solvent in serums, creams, and emulsions where clean-label positioning is a priority for the brand. In polymer and resin chemistry, it acts as a reactive intermediate and crosslinking agent, particularly in the synthesis of specialty polyols and high-performance industrial coatings. It also serves as a stabilizer in fuel blending applications, where it improves cold-flow properties and reduces oxidative degradation in modern biodiesel formulations. The material is supplied as a clear liquid in drum and IBC quantities suited to industrial procurement. Pharmaceutical-grade material is available to meet USP and BP specifications. Technical-grade product serves polymer and fuel applications. Purity levels typically range from 98% to 99%+ depending on the specific grade and the intended industrial end use. Contact us for supply of Solketal Request Quote

Other Names (Synonyms)

2,2-Dimethyl-1,3-dioxolane-4-methanol | Glycerol dimethylketal | Dioxolan | Isopropylidene glycerol | Glycerol acetonide | 2,3-Isopropylideneglycerol | 1,3-Dioxolane-4-methanol, 2,2-dimethyl- | 2,2-Dimethyl-5-hydroxymethyl-1,3-dioxolane

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-26.4 °C
Boiling Point188 °C
Density1.06 g/cm³
Flash Point176 °F
Appearanceclear colourless liquid
ColorClear colorless
FormLiquid
Water Solubilitymiscible
Vapor Pressure34Pa at 20℃
Refractive Indexn 20/D 1.434
pH4.0-7.5 (H2O)
Log P0.3 at 20℃

Safety & Handling

Warning
GHS07· IrritantGHS09· Environment

Hazard Statements

H315Causes skin irritation
H319Causes serious eye irritation
H411Toxic to aquatic life with long lasting effects

Precautionary Statements

P264Wash … thoroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P321Specific treatment (see … on this label).
P391Collect spillage.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29329970
Storage Class10 - Combustible liquids
WGK (Germany)2